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标题：Hepatoprotective and Anti-Hepatitis C Viral Activity of Platycodon grandiflorum Extract on Carbon Tetrachloride-Induced Acute Hepatic Injury in Mice
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作者：Tae-Won KIM ; Jong-Hwan LIM ; In-Bae SONG 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：2012
卷号：58
期号：3
页码：187-194
DOI：10.3177/jnsv.58.187
出版社：Center for Academic Publications Japan
摘要：The present study aims to evaluate the anti-HCV activity of hotwater extract from Platycodon grandiflorum (BC703) with HCV genotype 1b subgenomic replicon system and investigate its hepatoprotective activity on carbon tetrachloride (CCl₄)-induced acute liver damage in mice. BC703 produced significant hepatoprotective effects against CCl₄-induced acute hepatic injury by decreasing the activities of serum enzymes, nitric oxide and lipid peroxidation. Histopathological studies further substantiated the protective effect of BC703. Furthermore, BC703 inhibited the HCV RNA replication with an EC₅₀ value and selective index (CC₅₀/EC₅₀) of 2.82 μg/mL and above 35.46, respectively. However, digested BC703 using a simulated gastric juice showed poor protective effect against CCl₄-induced hepatotoxicity in mice and decreased anti-HCV activity as compared to the intact BC703. Although further studies are necessary, BC703 may be a beneficial agent for the management of acute hepatic injury and chronic HCV infection.
关键词：Platycodon grandilorum;carbon tetrachloride;hepatotoxicity;hepatitis C virus