文章基本信息

标题：Lactobacillus crispatus KT-11 Enhances Intestinal Immune Functions in C3H/HeN Mice
本地全文：下载
作者：Keisuke TOBITA ; Hiroyuki YANAKA ; Hajime OTANI 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：2010
卷号：56
期号：6
页码：441-445
DOI：10.3177/jnsv.56.441
出版社：Center for Academic Publications Japan
摘要：We investigated the effect of Lactobacillus crispatus KT-11 (KT-11) on intestinal immune systems in C3H/HeN mice. The level of intestinal total immunoglobulin (Ig) A was significantly higher in mice given KT-11 than in mice not given KT-11. Gene expression relating to antibody production and innate immune response increased more than 2-fold in the former compared with the later. Moreover, the number of IL-6⁺CD11b⁺ cells was significantly higher in Peyer's patch cells cultured with KT-11 than in those cultured without KT-11, although the number of CD4⁺ cells and the cell ratio of CD4⁺/CD8⁺ were remarkably lower in the culture with KT-11. These results indicate that KT-11 enhances intestinal IgA production and innate immune response in C3H/HeN mice.
关键词：Lactobacillus crispatus KT-11;immunoglobulin A;innate immune system;C3H/HeN mouse;Peyer's patch