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标题：Intestinal Permeability, Vitamin A Absorption and Serum Alpha-Tocopherol in Gastrointestinal Stromal Tumor Patients Treated with Imatinib
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作者：Bohuslav MELICHAR ; Markéta KAŠPAROVÁ ; Hana KALÁBOVÁ 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：2010
卷号：56
期号：6
页码：347-352
DOI：10.3177/jnsv.56.347
出版社：Center for Academic Publications Japan
摘要：Administration of imatinib is the therapy of choice in patients with advanced (inoperable) or metastatic gastrointestinal stromal tumors (GIST). Gastrointestinal toxicity is one of the most common side effects of anticancer therapy, including imatinib. Measurement of intestinal permeability represents a method of noninvasive laboratory assessment of gastrointestinal toxicity. We have measured intestinal permeability (by determining absorption of lactulose, mannitol and xylose), vitamin A absorption and serum alpha-tocopherol in 16 patients with advanced/metastatic GIST treated with imatinib. Lactulose/mannitol and lactulose/xylose ratios as well as parameters of vitamin A absorption did not change significantly during the treatment, but a significant decrease of alpha-tocopherol was observed. We conclude that, in contrast to most other anticancer agents studied so far, imatinib does not have an effect on intestinal permeability. No effect on vitamin A absorption was observed, but serum alpha-tocopherol decreased significantly during the treatment.
关键词：alpha-tocopherol;gastrointestinal stromal tumor;imatinib;intestinal permeability;vitamin A