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标题：Oral Administration of Acidic Xylooligosaccharides Prevents the Development of Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice
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作者：Takayuki OHBUCHI ; Makoto SAKAINO ; Tetsunari TAKAHASHI 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：2010
卷号：56
期号：1
页码：54-59
DOI：10.3177/jnsv.56.54
出版社：Center for Academic Publications Japan
摘要：We examined whether two types of xylooligosaccharides (neutral or acidic xylooligosaccharides) derived from hardwood kraft pulp ameliorate the development of atopic dermatitis (AD)-like skin lesions induced by repeated application of picryl chloride (PiCl) in NC/Nga mice. Oral administration of acidic xylooligosaccharides at a daily dose of 100 mg/kg significantly prevented the development of AD-like skin lesions. Serum histamine level was significantly suppressed, but serum total IgE level was not significantly suppressed. Moreover, the secretion of inflammatory cytokine IL-12 from splenic lymphocytes was significantly suppressed. On the other hand, neutral xylooligosaccharides showed no significant preventive effect on the development of AD-like symptoms. These results suggest that oral administration of acidic xylooligosaccharides may be effective in preventing the development of AD-like skin disease and one of the mechanisms is the suppressive effect on IL-12.
关键词：acidic xylooligosaccharides;prebiotics;atopic dermatitis;NC/Nga mouse;interleukin-12