文章基本信息

标题：Bioactive Substance from Grifola frondosa (Maitake) Mushroom Inhibits CCAAT Enhancer Binding Protein β and δ Expression on C3H10T1/2 B2C1 Adipocyte Cells
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作者：Katsuhiko MINAMINO ; Yuri YANAGA ; Masaru OHTSURU 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：2008
卷号：54
期号：3
页码：250-254
DOI：10.3177/jnsv.54.250
出版社：Center for Academic Publications Japan
摘要：Bioactive compound substances from Grifola frondosa (maitake) inhibited adipocyte differentiation of B₂C₁ preadipocytes. This compound is not related to MAP kinase (ERK1 and ERK2) cascades or β-catenin, which inhibit the expression of Glut4, PPARγ and C/EBPα. The compound reduced the expression time of C/EBPβ and C/EBPδ. These results suggest that the inhibitory action of these bioactive compounds on adipocyte differentiation is exhibited through preadipocytes. They cannot induce the expression of PPARγ or C/EBPα because of the reduced expression time of C/EBPβ and C/EBPδ.
关键词：Grifola frondosa (maitake);bioactive compound;adipocyte;CCAAT/enhancer binding protein (C/EBP);mechanism regulation