文章基本信息

标题：Urinary Water-Soluble Vitamins and Their Metabolite Contents as Nutritional Markers for Evaluating Vitamin Intakes in Young Japanese Women
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作者：Tsutomu FUKUWATARI ; Katsumi SHIBATA
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：2008
卷号：54
期号：3
页码：223-229
DOI：10.3177/jnsv.54.223
出版社：Center for Academic Publications Japan
摘要：Little information is available to estimate water-soluble vitamin intakes from urinary vitamins and their metabolite contents as possible nutritional markers. Determination of the relationships between the oral dose and urinary excretion of water-soluble vitamins in human subjects contributes to finding valid nutrition markers of water-soluble vitamin intakes. Six female Japanese college students were given a standard Japanese diet in the first week, the same diet with a synthesized water-soluble vitamin mixture as a diet with approximately onefold vitamin mixture based on Dietary Reference Intakes (DRIs) for Japanese in the second week, with a threefold vitamin mixture in the third week, and a sixfold mixture in the fourth week. Water-soluble vitamins and their metabolites were measured in the 24-h urine collected each week. All urinary vitamins and their metabolite levels except vitamin B₁₂ increased linearly in a dose-dependent manner, and highly correlated with vitamin intake ( r =0.959 for vitamin B₁, r =0.927 for vitamin B₂, r =0.965 for vitamin B₆, r =0.957 for niacin, r =0.934 for pantothenic acid, r =0.907 for folic acid, r =0.962 for biotin, and r =0.952 for vitamin C). These results suggest that measuring urinary water-soluble vitamins and their metabolite levels can be used as good nutritional markers for assessing vitamin intakes.
关键词：biomarker;human;urine;vitamin