文章基本信息

标题：Inhibitory Activities of Proanthocyanidins from Persimmon against Oxidative Stress and Digestive Enzymes Related to Diabetes
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作者：Young A LEE ; Eun Ju CHO ; Takashi TANAKA 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：2007
卷号：53
期号：3
页码：287-292
DOI：10.3177/jnsv.53.287
出版社：Center for Academic Publications Japan
摘要：The present study was carried out to evaluate the promising potential of polymers and oligomers from proanthocyanidins of persimmon peel as antioxidants and therapeutic agents for diabetes. Both polymers and oligomers showed the scavenging effect of 2,2-diphenyl-1-picrylhydrazyl, with IC₅₀ values of 4.35 and 2.41 μg/mL, respectively, and they also showed a protective activity against protein oxidation induced by 2,2'-azobis (2-amidinopropane) dihydrochloride. In particular, oligomers exerted a stronger activity against free radicals than polymers. In addition, to investigate their protective potential against diabetes-related pathological conditions, their inhibitory activities on digestive enzymes and advanced glycation endproduct (AGE) formation were evaluated. Polymers showed a strong inhibitory activity against α-amylase, while oligomers had a relatively weak effect. This suggests that the inhibition of α-amylase activity would probably depend on the degree of polymerization. On the other hand, against α-glucosidase activity and AGE formation, oligomers exerted a stronger protective effect than polymers. The present study suggests that polymers and oligomers from proanthocyanidins of persimmon peel could play a role as antidiabetic agents with antioxidative effects. Moreover, oligomers rather than polymers from proanthocyanidins of persimmon peel may be expected to be a more promising antioxidative and antidiabetic agent in relation to utilization in biological systems.
关键词：proanthocyanidins;oligomers;diabetes;antioxidant;persimmon