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标题：Genistein Enhances Antigen-Specific Cytokine Production in Female DO11.10 Transgenic Mice
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作者：Tohru SAKAI ; Mari KOGISO ; Kaori MITSUYA 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：2006
卷号：52
期号：5
页码：327-332
DOI：10.3177/jnsv.52.327
出版社：Center for Academic Publications Japan
摘要：Genistein is a phytoestrogen contained at high levels in soy products and has been shown to regulate immunoresponse. In this study, we evaluated the effects of genistein on the production of cytokines from antigen (Ag)-specific T cells using DO11.10 transgenic mice because the direct effect of genistein on Ag-specific cytokine production has not been elucidated. The oral administration of 20 mg/kg genistein increased IFN-γ and IL-4 production from DO11.10⁺ T cells in response to ovalbumin (OVA)_323-339 peptide in female DO11.10 mice. Analysis of intracellular cytokine synthesis revealed that the percentages of cytokine-producing cells in the control and genistein-treated groups were not different, indicating that increased cytokine production occurred at the single-cell level. In contrast to the female mice, genistein did not increase cytokine production in male mice, suggesting that the effect of genistein on cytokine production is gender-dependent.
关键词：soy isoflavon;genistein;cytokine;T cells;DO11.10 mice