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标题：Comparative Oral Toxicity of Coenzyme Q10 and Its (2Z)-Isomer in Rats: Single and Four-Week Repeated Dose Toxicity Studies
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作者：Shigeki HATAKEYAMA ; Shigeo KAWASE ; Ikuo YOSHIMURA 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：2006
卷号：52
期号：1
页码：9-20
DOI：10.3177/jnsv.52.9
出版社：Center for Academic Publications Japan
摘要：It has been reported that coenzyme Q₁₀ (CoQ₁₀) functions as an electron transfer carrier in mitochondria, and can produce an improvement in heart diseases such as congestive heart failure. Its (2Z)-isomer contains a cis -double bond at the 2-position of the decaprenyl side chain. As the original organic industrial synthesis of CoQ₁₀ resulted in a product that contained a small amount of this isomer, the efficacy and safety of CoQ₁₀ was determined using CoQ₁₀ containing this isomer; however, no toxicity data have been reported for the (2Z)-isomer itself. Thus, we conducted single (2,000 mg/kg) and 4-wk repeated (1,000 mg/kg) oral dose toxicity studies in rats to compare the toxicological profiles of CoQ₁₀ and its (2Z)-isomer. The two compounds displayed similar toxicological profiles, and it was concluded that neither CoQ₁₀ nor its (2Z)-isomer produce toxic effects in rats in single or repeated doses.
关键词：coenzyme Q10;CoQ10;ubiquinone;ubidecarenone