文章基本信息

标题：ニトロソアミンの生体内運命と代謝活性化
本地全文：下载
作者：望月正隆 ; 武田寧
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：1978
卷号：24
期号：6
页码：271-290
DOI：10.1248/jhs1956.24.271
出版社：The Pharmaceutical Society of Japan
摘要：The biological fate of nitrosamines, known as environmental carcinogens, and their metabolic activation in biological system are reviewed. This article includes the absorption, distribution, metabolism and excretion of dimethylnitrosamine, alkylation of nucleic acid bases with nitrosamines, metabolic activation of dialkylnitrosamines to produce alkyl cations as alkylating agents via α-hydroxylation, and the effects of substituents of α-carbon of dialkylnitrosamines on their biological activities. Emphasis has been placed to α-acetoxyalkylnitrosamines as masked compounds of α-hydroxylated active species. Their chemistry, carcinogenicity, and mutagenicity are compared. Organospecific carcinogenicity of dibutylnitrosamine and N-butyl-N-(4-hydroxybutyl) nitrosamine, urinary bladder carcinogens, are explained in terms of metabolism and metabolic activation.
关键词：dimethylnitrosamine;dibutylnitrosamine;dialkylnitrosamine;biological fate;metabolic activation;α-hydroxylation;α-acetoxydialkylnitrosamine;α-hydroperoxydialkylnitrosamine;mutagenicity;carcinogenicity