文章基本信息

标题：Chemicopharmacological Studies on Antispasmodic Action. IX. Precise Discrimination of Atropine-like Activity and Papaverine-like Activity as Competitive and Non-competitive Antagonism to Acetylcholine.
本地全文：下载
作者：Keijiro Takagi ; Issei Takayanagi
期刊名称：Chemical and Pharmaceutical Bulletin
印刷版ISSN：0009-2363
电子版ISSN：1347-5223
出版年度：1957
卷号：5
期号：6
页码：580-587
DOI：10.1248/cpb1953.5.580
出版社：The Pharmaceutical Society of Japan
摘要：(1) ACh dose-response curve in the presence of various concentrations of antagonist was traced fully and it was suggested experimentaly that the curve moved parallel by the atropine-like action and its maximum response was depressed noncompetitively by the papaverine-like action. (2) It was made possible to discriminate precisely the atropine-like action as competitive antagonism to a low concentration of ACh 4×10^-8g./cc. and the papaverinelike action as non-competitive antagonism to a high concentration of ACh (1.11×10^-4g./cc.). (3) The potency ratios in relaxing the contraction due to the high concentration of ACh was almost the same as the ratios against BaCl₂.