文章基本信息

标题：Remus: System for remote deep brain interventions
本地全文：下载
作者：Taylor D. Webb ; Matthew G. Wilson ; Henrik Odéen 等
期刊名称：iScience
印刷版ISSN：2589-0042
出版年度：2022
卷号：25
期号：11
页码：1-14
DOI：10.1016/j.isci.2022.105251
语种：English
出版社：Elsevier
摘要：SummaryTranscranial-focused ultrasound brings personalized medicine to the human brain. Ultrasound can modulate neural activity or release drugs in specific neural circuits but this personalized approach requires a system that delivers ultrasound into specified targets flexibly and on command. We developed a remote ultrasound system (Remus) that programmatically targets deep brain regions with high spatiotemporal precision and in a multi-focal manner. We validated these functions by modulating two deep brain nuclei—the left and right lateral geniculate nucleus—in a task-performing nonhuman primate. This flexible system will enable researchers and clinicians to diagnose and treat specific deep brain circuits in a noninvasive yet targeted manner, thus embodying the promise of personalized treatments of brain disorders.Graphical abstractDisplay OmittedHighlights•Remus delivers ultrasound into deep brain targets of task-performing subjects•Targets are specified programmatically and at high spatial and temporal precision•Brief pulses delivered to deep brain regions modulate visual choice behavior•The system enables reproducible daily applications and continuous safety monitoringBiological sciences; Biotechnology; Animal biotechnology; Biodevices.