文章基本信息

标题：Limited cross-variant immune response from SARS-CoV-2 Omicron BA.2 in naïve but not previously infected outpatients
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作者：Hye Kyung Lee ; Ludwig Knabl ; Mary Walter 等
期刊名称：iScience
印刷版ISSN：2589-0042
出版年度：2022
卷号：25
期号：11
页码：1-13
DOI：10.1016/j.isci.2022.105369
语种：English
出版社：Elsevier
摘要：SummaryOmicron is currently the dominant SARS-CoV-2 variant and several sublineages have emerged. Questions remain about the impact of previous SARS-CoV-2 exposure on cross-variant immune responses elicited by the SARS-CoV-2 Omicron sublineage BA.2 compared to BA.1. Here we show that without previous history of COVID-19, BA.2 infection induces a reduced immune response against all variants of concern (VOC) compared to BA.1 infection. The absence of ACE2 binding in sera of previously naïve BA.1 and BA.2 patients indicates a lack of meaningful neutralization. In contrast, anti-spike antibody levels and neutralizing activity greatly increased in the BA.1 and BA.2 patients with a previous history of COVID-19. Transcriptome analyses of peripheral immune cells showed significant differences in immune response and specific antibody generation between BA.1 and BA.2 patients as well as significant differences in the expression of specific immune genes. In summary, prior infection status significantly impacts the innate and adaptive immune response against VOC following BA.2 infection.Graphical abstractDisplay OmittedHighlights•Reduced immune response in Omicron BA.2 patients without previous history of COVID-19•Elevated immune response in BA.1 and BA.2 patients with a previous history of COVID-19•Distinct antibody creation and immune gene expression between BA.1 and BA.2 patientsImmune response; Virology; Transcriptomics.