文章基本信息

标题：Comparative analysis of within-host diversity among vaccinated COVID-19 patients infected with different SARS-CoV-2 variants
本地全文：下载
作者：Hebah A. Al-Khatib ; Maria K. Smatti ; Fatma H. Ali 等
期刊名称：iScience
印刷版ISSN：2589-0042
出版年度：2022
卷号：25
期号：11
页码：1-15
DOI：10.1016/j.isci.2022.105438
语种：English
出版社：Elsevier
摘要：SummarySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a rapidly evolving RNA virus that mutates within hosts and exists as viral quasispecies. Here, we evaluated the within-host diversity among vaccinated and unvaccinated individuals (n = 379) infected with different SARS-CoV-2 Variants of Concern. The majority of samples harbored less than 14 intra-host single-nucleotide variants (iSNVs). A deep analysis revealed a significantly higher intra-host diversity in Omicron samples than in other variants (p value Graphical abstractDisplay OmittedHighlights•Higher within-host diversity among omicron-positive samples•Higher within-host diversity among vaccinated individuals regardless of virus lineage•Limited impact of vaccine type on within-host diversity of SARS-CoV-2Immunology; Immune response; Virology; Genomics