文章基本信息

标题：Extensive neutralization against SARS-CoV-2 variants elicited by Omicron-specific subunit vaccine as a heterologous booster
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作者：Pai Peng ; Chengqian Feng ; Jie Hu 等
期刊名称：iScience
印刷版ISSN：2589-0042
出版年度：2022
卷号：25
期号：11
页码：1-15
DOI：10.1016/j.isci.2022.105465
语种：English
出版社：Elsevier
摘要：SummaryTo overcome the increased risk of SARS-CoV-2 reinfection or post-vaccination infection caused by the Omicron variant, Omicron-specific vaccines were considered a potential strategy. We reported the increased magnitude and breadth of antibody response against VOCs elicited by post-vaccination Delta and Omicron infection, compared to WT infection without vaccination. Then, in mouse models, three doses of Omicron-RBD immunization elicited comparable neutralizing antibody (NAb) titers with three doses of WT-RBD immunization, but the neutralizing activity was not cross-active. By contrast, a heterologous Omicron-RBD booster following two doses of WT-RBD immunization increased the NAb titers against Omicron by 9-folds than the homologous WT-RBD booster. Moreover, it retains neutralization against both WT and current VOCs. Results suggest that Omicron-specific subunit booster shows its advantages in the immune protection from both WT and current VOCs and that SARS-CoV-2 vaccines including two or more virus lineages might improve the NAb response.Graphical abstractDisplay OmittedHighlights•Post-vaccination SARS-CoV-2 infection can elicit higher and boarder immune response•A heterologous booster with the Omicron-RBD protein elicits a 9-fold increased NAb•Heterologous boosting with Omicron enhance the potency and breadth of immune responseVirology