文章基本信息

标题：Avaliação laboratorial da função hepática em pessoas iniciando a terapia antirretroviral com esquemas contendo Dolutegravir ou Efavirenz: estudo de coorte em Belo Horizonte, Brasil
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作者：Jorgino Julio Cesar ; Micheline Rosa Silveira ; Paulo Roberto Maia 等
期刊名称：Research, Society and Development
电子版ISSN：2525-3409
出版年度：2022
卷号：11
期号：13
页码：1-14
DOI：10.33448/rsd-v11i13.35082
语种：English
出版社：Grupo de Pesquisa Metodologias em Ensino e Aprendizagem em Ciências
摘要：Objective: to verify which antiretroviral treatment regimen was safer for people living with HIV, dolutegravir 50mg + lamivudine 300mg + tenofovir 300mg or efavirenz 600mg + lamivudine 300mg + tenofovir 300mg. For this, the following laboratory tests of liver function were analyzed: total, direct and indirect bilirubin, aspartate amino transferase, alanine amino transferase, gamma glutamyl transferase and alkaline phosphatase. Methodology: cohort study, with the follow-up of 234 people living with HIV and starting antiretroviral therapy in the city of Belo Horizonte, Minas Gerais, Brazil, with data collected between August 2015 and December 2018. Results: Mean values for the results of total and indirect bilirubin, aspartate amino transferase, alanine amino transferase and alkaline phosphatase tests reduced after 72 weeks for the two therapeutic regimens. The mean value for direct bilirubin in people taking efavirenz increased at 72 weeks and was above baseline compared to baseline. For gamma glutamyl transferase, the mean of the results was above the reference value in both groups before treatment. After 72 weeks of therapy with dolutegravir, the mean returned to baseline and, in the case of efavirenz, the mean remained high. Bonett's and Dunnett's tests had no statistical difference, indicating that the two therapeutic regimens are safe. Conclusions: the two therapeutic regimens studied proved to be safe and did not cause an increase in the variance for laboratory tests that were markers of liver function.
关键词：Highly Active Antiretroviral Therapy;Liver Cells;Drug response biomarkers.