文章基本信息

标题：Estudo do efeito de extratos do Ginkgo biloba e da quercetina no ducto deferente de camundongo
本地全文：下载
作者：Victória Bessa Alvarenga Lima ; Joaquim Maurício Duarte Almeida ; Priscila Totarelli Monteforte 等
期刊名称：Research, Society and Development
电子版ISSN：2525-3409
出版年度：2022
卷号：11
期号：12
页码：1-14
DOI：10.33448/rsd-v11i12.33441
语种：English
出版社：Grupo de Pesquisa Metodologias em Ensino e Aprendizagem em Ciências
摘要：Ginkgo biloba extract (GBE) has antioxidant, anti-inflammatory, and neuroprotective actions, and has a relaxing effect on smooth muscle organs. The vas deferens (DD) conducts the spermatozoa during ejaculation by the contraction of its muscles, and changes in this contraction can lead to disorders such as premature ejaculation (PE). PE is ejaculation that always or almost always occurs before or about 1 minute after vaginal penetration. Thus, our aim was to study the effect of GBE under the contraction of the DD of mice. The effect of GBE, here called GB2, or quercetin, was tested against contraction with potassium chloride. The effect of these substances was tested in the presence of nifedipine. We demonstrate that GB2, quercetin and nifedipine are able to inhibit the phasic and tonic components of the contraction. The effect of GB2 on the tonic component was enhanced in the presence of quercetin. Comparing the tonic component between GB2, Nifedipine+GB2 and Quercetin+GB2 groups, we observed that in the presence of nifedipine or quercetin, the effect of GB2 was potentiated. In the comparison of the Quercetin and Nifedipine+Quercetin groups, nifedipine potentiated the effect of quercetin under both components. These results indicate that GB2 and quercetin are able to inhibit some mechanism involved with the generation of DD contraction, and that this effect is not solely dependent on voltage-dependent calcium channel inhibition. These findings point out that GBE and quercetin, may be pharmacological strategies for the treatment of PE.
关键词：Herbal medicines;Premature ejaculation;Ginkgo biloba;Quercetin;Vas deferens.