文章基本信息

标题：Avaliação do uso de amido resistente na prevenção de colite provocada pelo antibiótico tetraciclina
本地全文：下载
作者：Armindo Antonio Alves ; Bruna Lago Tagliapietra ; Grasiela Dias de Campos Severi-Aguiar 等
期刊名称：Research, Society and Development
电子版ISSN：2525-3409
出版年度：2022
卷号：11
期号：11
页码：1-13
DOI：10.33448/rsd-v11i11.34080
语种：English
出版社：Grupo de Pesquisa Metodologias em Ensino e Aprendizagem em Ciências
摘要：This study aimed to evaluate the effect of diets with resistant starches in preventing the occurrence and/or severity of pseudomembranous colitis in animals treated with and without the antibiotic tetracycline. The experiment was carried out with 20 female Wistar rats, divided into four groups that received different diets: pregelatinized starch with 9.5% resistant starch; pregelatinized starch with 9.5% resistant starch and tetracycline; pregelatinized starch and resistant starch with 18.1% resistant starch and pregelatinized starch and resistant starch with 18.1% resistant starch and tetracycline. Weight, feed and water consumption were monitored for 21 days and analysis of total cholesterol, triglycerides and liver, muscle and cardiac glycogen were performed. Histological analysis of staining by hematoxylin-eosin and periodic acid Schiff of the animals' large intestine was performed. The results showed changes in the cytoarchitecture of the intestinal colon of the animals, which varied according to the treatment to which they were submitted, showing from mucosal atrophy in animals that received tetracycline, the formation of edema and congestion of vessels in the submucosa in animals fed 18 .1% of resistant starch and the presence of cellular debris in the lumen of the organ and loss of brush border when it was associated with tetracycline, demonstrating changes in the absorption and intestinal functioning of the animals, which contributes to the loss of organ homeostasis.
关键词：Resistant starch;Experimental diets;Histological analysis;Triglycerides;Glycogen;Cholesterol.