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标题：Potencial antifúngico "in vitro" de extratos foliares de espécies de Justicia L. (Acanthaceae) diante de isolados clínicos veterinários de dermatófitos
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作者：Paulo Roberto Lima de Azevedo Junior ; Rickson Alves Marques de Oliveira ; Marcela Barlette Mendes 等
期刊名称：Research, Society and Development
电子版ISSN：2525-3409
出版年度：2022
卷号：11
期号：10
页码：1-7
DOI：10.33448/rsd-v11i10.32346
语种：English
出版社：Grupo de Pesquisa Metodologias em Ensino e Aprendizagem em Ciências
摘要：Dermatophytes are keratinophilic fungi, which digest the keratin of skin, hair and nails, using it as a nutrient. By this nature they are able to invade these tissues, thus causing infections called dermatophytosis. One of the main classes of antifungals used in the treatment of dermatophytosis is the azoles. Due to the increasing resistance of fungi to these drugs, new compounds are increasingly being sought in order to overcome this problem. Justicia paracambi and Justicia wasshauseniana are native plant species to the Brazilian territory, which belong to a genus known to have medicinal properties. Thus, the objective of the present work was to evaluate the activity of commercial antifungal agents, and the antifungal activity of hydroalcoholic and aqueous extracts of J. paracambi and J. wasshauseniana on dermatophytes from veterinary clinical samples. Assays were performed using the paper disk diffusion technique as described by Kirby-Bauer, using extracts from the leaves of the aforementioned plants and commercial antifungal disks. According to the results, ketoconazole showed the highest antifungal activity and miconazole the lowest. Regarding the extracts, the aqueous of J. paracambi showed higher antifungal activity. It is concluded that J. paracambi and J. wasshauseniana have antifungal potential to be explored as an alternative to traditional commercial drugs, mainly by observing the zones of inhibition produced by the aqueous extract of J. paracambi.
关键词：Antimicrobials;Azoles;Dermatophytosis;Plants;Resistance.