文章基本信息

标题：Avaliação do uso da toxina botulínica do tipo A para regressão de estrabismo: uma revisão sistemática de literatura
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作者：Júlia Fernandes Nogueira ; Bárbara Queiroz de Figueiredo ; Daniel Henrique Mendes Batista 等
期刊名称：Research, Society and Development
电子版ISSN：2525-3409
出版年度：2022
卷号：11
期号：10
页码：1-6
DOI：10.33448/rsd-v11i10.32703
语种：English
出版社：Grupo de Pesquisa Metodologias em Ensino e Aprendizagem em Ciências
摘要：Botulinum toxin (BT) presents itself as a less invasive alternative for the correction of strabismus, acting by the high affinity for cholinergic synapses, which causes a blockage of acetylcholine release. Such application, consequently, causes a lower chemical-neural receptivity, reducing muscle responsiveness to contracture, not causing, however, complete paralysis. Through this mechanism, the injection of botulinum toxin type A (TBA) into the extraocular muscles allows the alteration of ocular alignment creating a temporary paralysis, producing an overcorrection of the strabismus in which a shortening of the antagonist muscle is induced. Histologically, a change in sarcomere density may occur, which favors permanent ocular alignment. In a partial analysis, several authors report good results with the use of TBA in the treatment of different presentations of strabismus. There are several classifications of indication, expected effects, and adverse effects through the procedure, which must be considered upon patient admission. Thus, botulinum toxin, injected intramuscularly, binds to terminal receptors found in motor nerves, acting by blocking the release of acetylcholine in the presynaptic terminal, deactivating fusion proteins, which prevents the release of acetylcholine in the synaptic cleft, which does not allow depolarization of the postsynaptic terminal, blocking muscle contraction by temporary chemical denervation.
关键词：Strabismus;Botulinum toxin type A;Acetylcholine.