摘要:The Ebinur Lake Basin is an important ecological area in China. The sustainable development of the basin is imperative, particularly the coupling and coordination between the agro-ecological environment and economy. Six counties in the Ebinur Lake Basin were studied and CRITIC—the entropy weight method used in the construction of regional agro-ecosystem and economic evaluation index systems for 2001–2021. The entropy weight method and coupling coordination were used to evaluate and analyze the systems. The results indicate that: (1) The integrated index grew slowly, increasing from 0.15 in 2000 to 0.18 in 2020. The agro-economic integrated index grew rapidly, increasing from 0.08 in 2000 to 0.25 in 2020. (2) High quality coupling was achieved from 2000 to 2010, with 50% superior coupling in 2010, which then decreased to reach 17% in 2020. (3) The agro-ecological–economic system coupling was high at 0.8; however, the coordination degree was low, at 0.36. (4) Most counties suffered from economic lag before 2010, with an average Ue/Us of 0.93 in 2010. Ecological lag has dominated since 2010, and the average Ue/Us value reached 1.48 in 2015. Coupling and coordinating the agro-ecological and economic systems is important for the sustainable development of local agriculture.