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标题：Comparing the two concentrations of Co 0.6 Zn 0.4 Fe 2O 4 nanoparticles coated with dimercaptosuccinic acid based on T2-and T2*- weighted MRI: An animal study
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作者：Leyla Ansari ; Alireza Shahhamzeh ; Danial Seifi Makrani 等
期刊名称：Journal of Radiation Research and Applied Sciences
印刷版ISSN：1687-8507
出版年度：2022
卷号：15
期号：2
页码：84-89
DOI：10.1016/j.jrras.2022.05.008
语种：English
出版社：Elsevier B.V.
摘要：AbstractPurposeThis study aimed to compare two different concentrations of Cobalt-zinc (Co–Zn) ferrite (Co0.6Zn0.4Fe2O4or CZFO) nanoparticles (NPs) included 1.5 and 2.5 mg Fe/kg coated with dimercaptosuccinic acid (DMSA) based on T2-and T2*- weighted magnetic resonance imaging (MRI) of rats liver.Materials and methodsThe structural and crystal phase of CZFO magnetic NPs were determined using X-ray diffraction (XRD) and FTIR analysis. Two groups of rats (six for each group) were studied, in which the first and second groups received 1.5 and 2.5 mg/ml of Fe/kg body weight of the mentioned NPs, respectively. After the injection of the NPs, the signal intensity of the liver at different times (30, 38, 75, and 120 min) as well as the pathological characteristics of the liver and kidney tissues (24 h after injection) were investigated for the two groups.ResultsFor group 1, the maximum contrast enhancement in the rat liver was 58.46% and 77.13% occurred at 30 and 120 min, respectively, for T2and for T2* weighted images. For group 2, these values were obtained at 57.96% and 75.77% occurred at 30 and 75 min, respectively. There was not found a remarkable iron in the kidney tissue, however, a small amount of iron was observed in the two rats livers for each investigated group, which was negligible after 24 h.ConclusionOur results demonstrated that for both investigated groups, it seems that the synthesized CZFO NPs coated with DMSA are appropriate agents for increasing the contrast intensity based on T2-and T2*- weighted MR imaging in rat liver.
关键词：KeywordsenMagnetic resonance imaging (MRI)T2-and T2*- weightedCo0.6Zn0.4Fe2O4NanoparticlesDimercaptosuccinic acid (DMSA)Rat liver