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标题：The Role of Titanium Particles and Ions in the Pathogenesis of Peri-Implantitis
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作者：Farah Asa’ad ; Peter Thomsen ; Marcel F. Kunrath 等
期刊名称：Journal of Bone Metabolism
印刷版ISSN：2287-6375
出版年度：2022
卷号：29
期号：3
页码：145-154
DOI：10.11005/jbm.2022.29.3.145
语种：English
出版社：The Korean Society for Bone and Mineral Research
摘要：Titanium (Ti) particles and ions have been investigated in recent years as important factors in the pathogenesis of peri-implantitis. However, their role in the pathogenesis is yet to be fully understood. A review of pertinent literature was performed in various databases to determine the current position of Ti particles and ions role in the pathogenesis of peri-implantitis. There are several in vitro, preclinical and clinical published studies that have addressed the role of Ti particles and ions in the pathogenesis of peri-implantitis. These studies explored the effect of Ti particles and ions in the pathogenesis of peri-implantitis with respect to foreign body reaction, cellular response, epigenetic mechanisms, namely DNA methylation, and the oral microbiome. Studies have shown that the release of Ti particles/ions during implant insertion, early healing stages, late healing stages, and treatments during peri-implantitis might contribute to peri-implantitis through different mechanisms, such as foreign body reaction, cellular response, DNA methylation, and shaping the oral microbiome by increasing dysbiosis. However, further studies are needed to elucidate the complex interactions between all these mechanisms and Ti particles/ions in the pathogenesis and progression of peri-implantitis.
关键词：Dental implants;DNA methylation;Foreign-body reaction;Microbiota;Peri-implantitis;Titanium