文章基本信息

标题：Deterministic models to decipher the lag phase duration during diauxie
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作者：Florian Dupeuble ; Alain Rapaport ; Thomas Guilmeau 等
期刊名称：IFAC PapersOnLine
印刷版ISSN：2405-8963
出版年度：2022
卷号：55
期号：20
页码：481-486
DOI：10.1016/j.ifacol.2022.09.141
语种：English
出版社：Elsevier
摘要：AbstractThe deterministic model developed by Graham et al. [2020], which is the approximation in large population of a stochastic model, allowed the authors to propose a ‘macroscopic description’ of metabolic heterogeneity ofEscherichia coligrowing on glucose and xylose. However, these models did not include any mechanistic model to explain the variations of the duration of the ‘lag-phase’ observed when the glucose is exhausted and before the xylose is being consumed. Here, we propose a deterministic mechanistic model to explain howE. coliswitches its consumption of a sugar to another one depending on the dynamic of intracellular XylR molecules. The model is developed and investigated numerically. It reveals some important observability issues.
关键词：KeywordsDiauxic growthdeterministic modelingODEmass-balance modelssimulation