文章基本信息

标题：Citidine-5-diphosphocholine Ameliorates the Impairment of Spatial Memory Induced by Scopolamine
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作者：Kotaro Takasaki ; Kenichi Mishima ; Masahiko Morita 等
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：2011
卷号：57
期号：5
页码：432-435
DOI：10.1248/jhs.57.432
出版社：The Pharmaceutical Society of Japan
摘要：The memory enhancing effects of orally administered citidine-5-diphosphocholine or citicoline (CDP-choline) on memory impairment without neuronal cell death are still unknown. We investigated the effects of CDP-choline on memory disturbance induced by scopolamine using an eight-armed radial maze task. Orally repeated administration of CDP-choline or histidine significantly restored the errors impaired by scopolamine. CDP-choline may increase hippocampal and neocortical acetylcholine levels. These results suggest that CDP-choline has ameliorative effects on the impairment of spatial memory induced not only by neuronal cell death but also by impaired cholinergic signal.
关键词：citidine-5-diphosphocholine;scopolamine;spatial memory