文章基本信息

标题：Estrogenic Activity of Alkyl(thio)phenols and 4,4'-thiodiphenol Formed from Degradation of Commercial Insecticides
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作者：Kenta Yamada ; Masanori Terasaki ; Masakazu Makino 等
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：2011
卷号：57
期号：2
页码：134-141
DOI：10.1248/jhs.57.134
出版社：The Pharmaceutical Society of Japan
摘要：We investigated the estrogenic activity of commercial insecticides fenamiphos, fenthion, methiocarb, propaphos, sulprophos, and temephos as well as some phenolic compounds obtained as a result of their degradation. Using a yeast two-hybrid assay, the relative activities of 4-(methylthio)phenol, 3-methyl-4-(methylthio)phenol, 3,5-dimethyl-4-(methylthio)phenol, and 4,4'-thiodiphenol (TDP) were evaluated as 11, 10, 4, and 1000% (10 times) that of bisphenol-A. To reveal the binding abilities of the abovementioned phenolic compounds with respect to human estrogen receptor α (hERα), we carried out ER-ELISA and found that all compounds had significant abilities, particularly, TDP. From the viewpoint of bioisosterism, we discussed the similarity between a vinylene-group, -CH=CH-, and a thioether-group, -S-. We suggest that an alkylthio-group substituted at the “ para ”-position of a phenol ring plays a key role in the binding abilities of the investigated phenolic compounds.
关键词：alkyl(thio)phenol;estrogenic activity;bioisosterism