文章基本信息

标题：Safety Evaluation of Black Rice Vinegar (Kurosu) from a Jar on Food-drug Interaction: 30-day Ingestion Study on Expressions of Drug Metabolism Enzymes and Transporters in Rats
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作者：Yoshihiko Shibayama ; Masanobu Nagano ; Akira Fujii 等
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：2010
卷号：56
期号：6
页码：712-716
DOI：10.1248/jhs.56.712
出版社：The Pharmaceutical Society of Japan
摘要：Black rice vinegar (kurosu) made from a jar is a traditional vinegar in Japan. Kurosu has been commonly used as a healthcare supplement; however, it is not clear whether kurosu has a treatment effect on the expression of drug metabolism enzymes and transporters, whose expression alterations may induce food-drug interaction. Alteration of the principal drug metabolism enzymes and expression following kurosu and moromi, the residue from black vinegar brewing, for 30-day treatment was evaluated. Water, 0.23% acetic acid, concentrated kurosu (containing 0.23% acetic acid) and moromi was administered to Wister rats. The treatment did not significantly affect the biochemical parameters of serum, alanine aminotransferase, alkaline phosphatase, total protein, creatinine in the serum, and body weight. The treatment also did not affect the expression levels of cytochrome P450 (Cyp) 1a2, Cyp2b1/2, Cyp3a1, glutathione S -transferase, p-glycoprotein, multidrug resistance protein 2, breast cancer resistance protein, organic anion transport polypeptide 2, and organic anion transport 2 and 3 in the liver. In conclusion, the present study suggests that kurosu from a jar does not have toxic effect and does not alter expression levels of principal drug metabolism enzymes and transporters.
关键词：black rice vinegar;cytochrome P450;transporter