文章基本信息

标题：Abietic Acid from Resina Pini of Pinus Species as a Testosterone 5α-Reductase Inhibitor
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作者：Seong-Soo Roh ; Moon-Ki Park ; Yong-ung Kim 等
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：2010
卷号：56
期号：4
页码：451-455
DOI：10.1248/jhs.56.451
出版社：The Pharmaceutical Society of Japan
摘要：The 50% ethanol extracts from Resina Pini of Pinus sp. (Pinaceae) showed more potent inhibitory activity against testosterone 5α-reductase prepared from rat prostate than those from several medicinal plants used for the treatment of androgen-dependent diseases such as benign prostatic hyperplasia. The fraction responsible for this activity was purified, and the active constituent was isolated and identified as abietic acid, a diterpene resin acid, which exhibited potent testosterone 5α-reductase inhibitory activity. Methyl abietate was substantially inactive against testosterone 5α-reductase, whereas other diterpene resin acids, pimaric acid and neoabietic acid, were as active as abietic acid against testosterone 5α-reductase, indicating that the negatively charged anionic carboxyl group on the molecule is an important structural moiety for the inhibitory activity. These findings suggest that a nonsteroidal anionic diterpene compound of natural origin may have the potential to act as a transition state analogue inhibitor of testosterone 5α-reductase in the treatment of androgen-dependent diseases.
关键词：abietic acid;Resina Pini;testosterone 5α-reductase inhibitor;resin acid;Pinus sp.;androgen-dependent disease