文章基本信息

标题：Oxidative Stress More Strongly Induced by ortho- Than para-quinoid Polycyclic Aromatic Hydrocarbons in A549 Cells
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作者：Yumi Motoyama ; Kanae Bekki ; Sang Woon Chung 等
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：2009
卷号：55
期号：5
页码：845-850
DOI：10.1248/jhs.55.845
出版社：The Pharmaceutical Society of Japan
摘要：The effect of four ortho -quinoid polycyclic aromatic hydrocarbons (PAHs) and seven para -quinoid PAHs on the viability of A549 cells were examined. The ortho -quinoid PAHs [1,2-naphthoquinone (1,2-NQ), 9,10-phenanthrenquinone (9,10-PQ), 5,6-chrysenequinone (5,6-CQ), and benzo[ c ]phenanthrene-5,6-quinone (B[ c ]P-5,6-Q)] overproduced hydrogen peroxide (H₂O₂) without being consumed themselves. These ortho -quinoid had strong cytotoxic effects except for 1,2-NQ, since of its tendency to covalently bind to thiol groups. The cytotoxicity appears to be due to the overproduction of H₂O₂ by ortho -quinoid PAHs in a redox cycle coupled with the consumption of thiol group. In contrast, the para -quinoid PAHs were not as strong cytotoxic and did not produce H₂O₂.
关键词：ortho-quinoid polycyclic aromatic hydrocarbon;hydrogen peroxide;redox cycle;oxidative stress;cytotoxicity