文章基本信息

标题：Effect of Momordica charantia on Adenosine Monophosphate-activated Protein Kinase in Genetically Type 2 Diabetic Mice Muscle
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作者：Toshihiro Miura ; Takanori Kawata ; Satoshi Takagi 等
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：2009
卷号：55
期号：5
页码：805-808
DOI：10.1248/jhs.55.805
出版社：The Pharmaceutical Society of Japan
摘要：The hypoglycemic activity of Momordica charantia L. (Cucurbitaceae) (MC) was investigated in KK-Ay mice, an animal model of type 2 diabetes. The water extract of the fruit of MC (100 mg/kg) reduced the blood glucose of KK-Ay mice 2 and 4 hr after oral administration ( p <0.05). In addition, the muscle adenosine monophosphate-activated protein kinase (AMPK) was significantly activated in the orally MC-treated mice when compared to that of the controls ( p <0.01). These results suggest that the antidiabetic effect of MC is derived, at least in part, from an activation of AMPK in the muscle.
关键词：adenosine monophosphate-activated protein kinase;hypoglycemic effect;KK-Ay;Momordica charantia;Cucurbitaceae