文章基本信息

标题：Direct Analysis of Conjugate Metabolites of Methamphetamine, 3,4-Methylenedioxymethamphetamine, and Their Designer Drugs in Biological Fluids
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作者：Noriaki Shima ; Munehiro Katagi ; Hitoshi Tsuchihashi 等
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：2009
卷号：55
期号：4
页码：495-502
DOI：10.1248/jhs.55.495
出版社：The Pharmaceutical Society of Japan
摘要：This review summarizes technical improvements in the forensic analysis for conjugate metabolites of methamphetamine (MA), 3,4-methylenedioxymethamphetamine (MDMA) and their designer drugs. The improvements include the establishments of liquid chromatography-mass spectrometry-mass spectrometry (LC-MS-MS) in combination with the pretreatment methods. The direct determination techniques for the conjugates proved to be effective in rapidly and accurately examining many biological specimens without annoying hydrolysis. The metabolism of MA and MDMA, with attention to the phase II metabolism of the major hydroxy metabolites, is also discussed based on concentration data in biological specimens obtained from drug abusers.
关键词：methamphetamine;3,4-methylenedioxymethamphetamine;conjugate metabolite;liquid chromatography-mass spectrometry;direct analysis