文章基本信息

标题：Characteristic Properties of Genipin as an Activator in Neuronal Nitric Oxide Synthase
作者：Hirokazu Suzuki ; Matsumi Yamazaki ; Kenzo Chiba 等
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：2007
卷号：53
期号：6
页码：730-733
DOI：10.1248/jhs.53.730
出版社：The Pharmaceutical Society of Japan
摘要：The present investigation was undertaken to compare the structural and electronic properties of genipin with those of tetrahydrobiopterin (H₄B), an essential cofactor in neuronal nitric oxide synthase (nNOS), and 4-aminotetrahydrobiopterin (4-amino-H₄B), an inhibitor of nNOS, using computer-assisted molecular modeling techniques. Molecular modeling, superimposing, and docking simulation, in addition to LUMO-energy calculation, revealed that genipin has structural and electronic properties that markedly resemble those of H₄B.
关键词：genipin;tetrahydrobiopterin;4-aminotetrahydrobiopterin;molecular modeling;neuronal nitric oxide synthase