Amphetamines and their analogues have undergone a cycle of popularity as recreational drugs in Japan. The current wave of popularity began in the early 1990s and spread throughout the country. More recently, not only 3,4-methylenedioxymethamphetamine (MDMA) but also other designer amphetamines analogues, including p -methoxyamphetamine (PMA), 2,5-dimethoxy-4-ethylthiophenethylamine (2C-T-2), etc ., have been extensively and increasingly abused, mainly among juveniles. This minireview presents an update on the amphetamines and their analogues by focusing on clandestine tablets encountered in Japan recently.