文章基本信息

标题：Modification of 3'-AMP Forming Enzyme Activity by a Potent Immunosuppressant, ISP-I/Myriocin, in Liver of Mice Treated with Carbon Tetrachloride
作者：Hiroyuki Fujimori ; Tetsuro Fujita ; Hidemitsu Pan-Hou 等
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：2001
卷号：47
期号：3
页码：314-317
DOI：10.1248/jhs.47.314
出版社：The Pharmaceutical Society of Japan
摘要：The effect of ISP-I/myriocin on adenosine 3'-monophosphate (3'-AMP) forming enzyme activity in carbon tetrachloride (CCl₄)-induced hepatitis was examined. The 3'-AMP forming enzyme activity in mouse liver was enhanced by the treatment of CCl₄. The increase in the activity in cytosol may result from the leakage of the enzyme from mitochondria via the damage of mitochondrial membrane induced by CCl₄. Pretreatment of mice with ISP-I/myriocin for 24 hr, significantly inhibited both the CCl₄-induced activities of serum alanine aminotransferase and the 3'-AMP forming enzyme in the supernatant of liver homogenate prepared immediately after the organ excision. These results suggest that the inhibitory effects of ISP-I/myriocin may be due to inhibition of lipid peroxidation of intracellular membranes caused by CCl₄, in turn inhibiting the leakage of the 3'-AMP forming enzyme from mitochondria to cytosol. Our results demonstrated for the first time that ISP-I/myriocin has a protective effect on the CCl₄-induced hepatotoxicity.
关键词：adenosine 3'-monophosphate forming enzyme;ISP-I/myriocin;carbon tetrachloride;adenosine 3'-monophosphate;mouse liver