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标题：The effect of cryoprecipitate on prevention of intra cerebral hemorrhage and brain contusion expansion in traumatic patients
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作者：Hamidreza Saeidiborojeni ; Alireza Tahmoures ; Mehdi Naderi 等
期刊名称：JOURNAL OF INJURY & VIOLENCE RESEARCH
印刷版ISSN：2008-2053
电子版ISSN：2008-4072
出版年度：2022
卷号：14
期号：3
页码：183-189
DOI：10.5249/jivr.v14i3.1763
语种：English
出版社：KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES
摘要：Background: Traumatic brain injury (TBI) is a general and socioeconomic complication and is one of the important causes of mortality and disability among young people in the world. Falling and violence and sports injuries are the other cause. It causes for about ten million new patients, accounting for 9% of all deaths. This interventional study aims to investigate the effects of early administration of cryoprecipitate to prevent expansion of intracranial hemorrhage. Methods: This randomized clinical trial recruited 54 non-pregnant patients. 27 patients in the control group and 27patients in the interventional group. For all patients, common and accepted procedures in scientific centers, including anticonvulsant drugs, normal saline and the other routine management was done and only for patients in the intervention group, 4 units of cryoprecipitate were added to their routine treatments; computed tomography scan (CT) scan was performed 48 hours later in both groups and finally the contusion size was compared in both groups. Results: It was observed in the intervention group that by adding 4 units of cryoprecipitate to their treatments; they had no increased size of the brain parenchymal contusion according to the criteria defined in the study compared to the control group (OR: 0.08, 95% CI: 0.0102_0.6303) Conclusion: According to a clinical trial, it seems that cryoprecipitate can prevent of cerebral parenchymal hemorrhage expansion in traumatic patients.