文章基本信息

标题：Proteomic characterisation of triple negative breast cancer cells following CDK4/6 inhibition
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作者：Melina Beykou ; Mar Arias-Garcia ; Theodoros I.Roumeliotis 等
期刊名称：Scientific Data
电子版ISSN：2052-4463
出版年度：2022
卷号：9
期号：1
页码：1-13
DOI：10.1038/s41597-022-01512-1
语种：English
出版社：Nature Publishing Group
摘要：When used in combination with hormone treatment, Palbociclib prolongs progression-free survival of patients with hormone receptor positive breast cancer. Mechanistically, Palbociclib inhibits CDK4/6 activity but the basis for difering sensitivity of cancer to Palbociclib is poorly understood . A common observation in a subset of Triple Negative Breast Cancers (TNBCs) is that prolonged CDK4/6 inhibition can engage a senescence-like state where cells exit the cell cycle, whilst, remaining metabolically active . To better understand the senescence-like cell state which arises after Palbociclib treatment we used mass spectrometry to quantify the proteome, phosphoproteome, and secretome of Palbociclib- treated MDA-MB-231 TNBC cells . We observed altered levels of cell cycle regulators, immune response, and key senescence markers upon Palbociclib treatment . These datasets provide a starting point for the derivation of biomarkers which could inform the future use CDK4/6 inhibitors in TNBC subtypes and guide the development of potential combination therapies .