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  • 标题:Proteomic characterisation of triple negative breast cancer cells following CDK4/6 inhibition
  • 本地全文:下载
  • 作者:Melina Beykou ; Mar Arias-Garcia ; Theodoros I.Roumeliotis
  • 期刊名称:Scientific Data
  • 电子版ISSN:2052-4463
  • 出版年度:2022
  • 卷号:9
  • 期号:1
  • 页码:1-13
  • DOI:10.1038/s41597-022-01512-1
  • 语种:English
  • 出版社:Nature Publishing Group
  • 摘要:When used in combination with hormone treatment, Palbociclib prolongs progression-free survival of patients with hormone receptor positive breast cancer. Mechanistically, Palbociclib inhibits CDK4/6 activity but the basis for difering sensitivity of cancer to Palbociclib is poorly understood . A common observation in a subset of Triple Negative Breast Cancers (TNBCs) is that prolonged CDK4/6 inhibition can engage a senescence-like state where cells exit the cell cycle, whilst, remaining metabolically active . To better understand the senescence-like cell state which arises after Palbociclib treatment we used mass spectrometry to quantify the proteome, phosphoproteome, and secretome of Palbociclib- treated MDA-MB-231 TNBC cells . We observed altered levels of cell cycle regulators, immune response, and key senescence markers upon Palbociclib treatment . These datasets provide a starting point for the derivation of biomarkers which could inform the future use CDK4/6 inhibitors in TNBC subtypes and guide the development of potential combination therapies .
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