文章基本信息

标题：RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients
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作者：JohnD.Isaacs ; Sarah Brockbank ; AyakoWakatsuki Pedersen 等
期刊名称：Scientific Data
电子版ISSN：2052-4463
出版年度：2022
卷号：9
期号：1
页码：1-13
DOI：10.1038/s41597-022-01264-y
语种：English
出版社：Nature Publishing Group
摘要：Rheumatoid arthritis (RA) is a chronic infammatory disorder with poorly defned aetiology characterised by synovial infammation with variable disease severity and drug responsiveness . To investigate the peripheral blood immune cell landscape of early, drug naive RA, we performed comprehensive clinical and molecular profling of 267 RA patients and 52 healthy vaccine recipients for up to 18 months to establish a high quality sample biobank including plasma, serum, peripheral blood cells, urine, genomic DNA, RNA from whole blood, lymphocyte and monocyte subsets . We have performed extensive multi-omic immune phenotyping, including genomic, metabolomic, proteomic, transcriptomic and autoantibody profling . We anticipate that these detailed clinical and molecular data will serve as a fundamental resource ofering insights into immune-mediated disease pathogenesis, progression and therapeutic response, ultimately contributing to the development and application of targeted therapies for RA .