首页    期刊浏览 2024年11月29日 星期五
登录注册

文章基本信息

  • 标题:Field Study of Inactivated Equine Rotavirus Vaccine
  • 本地全文:下载
  • 作者:Hiroshi IMAGAWA ; Tetsuo KATO ; Hiroshi TSUNEMITSU
  • 期刊名称:Journal of Equine Science
  • 印刷版ISSN:1340-3516
  • 电子版ISSN:1347-7501
  • 出版年度:2005
  • 卷号:16
  • 期号:2
  • 页码:35-44
  • DOI:10.1294/jes.16.35
  • 出版社:Japanese Society of Equine Science
  • 摘要:We aimed to determine the safety, immunogenicity and efficiency of an inactivated equine rotavirus vaccine. The vaccine was prepared with G3 serotype equine rotavirus. A dose of 2 ml was inoculated twice with a 1-month interval into the cervical muscles of 60 pregnant mares (40 on farm T and 20 on farm M). The first vaccination was conducted 2 or 3 months before full term. No abnormal signs were observed in the whole body or the inoculated area in any of the mares vaccinated. Serum neutralization antibody rose in 56 (93.3%) of the 60 vaccinated mares. The 60 foals born to the vaccinated mares possessed neutralization antibody titers of 1:320 to 1:10240. Sixteen foals on farm T developed diarrhea caused by serotype G14 rotavirus infection, but no foals on farm M developed diarrhea. Diarrhea in the foals born to vaccinated mares was a slight illness in comparison with that in foals born to unvaccinated mares. The vaccine is safe and immunogenic for pregnant mares, and vaccine-induced maternal antibody in the foals can reduce the signs of diarrhea caused by rotavirus infection.
  • 关键词:diarrhea;equine;rotavirus;vaccine
国家哲学社会科学文献中心版权所有