文章基本信息

标题：Effect of Maternal Smoking Cessation Before and During Early Pregnancy on Fetal and Childhood Growth
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作者：Kohta Suzuki ; Miri Sato ; Wei Zheng 等
期刊名称：Journal of Epidemiology
印刷版ISSN：0917-5040
电子版ISSN：1349-9092
出版年度：2014
卷号：24
期号：1
页码：60-66
DOI：10.2188/jea.JE20130083
出版社：Japan Epidemiological Association
摘要：Background: Maternal smoking during pregnancy is a major cause of intrauterine growth restriction and childhood obesity, but only a few studies have examined the association of smoking cessation before and during pregnancy with fetal and childhood growth. We examined this association in a prospective cohort study in Japan. Methods: Our study included children born between 1991 and 2006 and their mothers. Using a questionnaire, maternal smoking status was recorded at pregnancy. The anthropometric data of the children were collected during a medical check-up at age 3 years. Multiple linear and logistic regression models were used for data analysis stratified by sex. Results: In total, 2663 mothers reported their smoking status during early pregnancy, and data were collected from 2230 (83.7%) children at age 3 years. Maternal smoking during pregnancy was associated with a significant reduction in birth weight (approximately 120–150 g). Body mass index at age 3 years was significantly higher among boys born to smoking mothers than among boys born to nonsmoking mothers. Maternal smoking during pregnancy was associated with overweight at age 3 years among boys (adjusted odds ratio, 2.4; 95% CI, 1.03–5.4). However, among women who stopped smoking in early pregnancy, there was no increase in the risks of a small for gestational age birth or childhood overweight at age 3 years. Conclusions: Children born to mothers who stopped smoking before or during early pregnancy had appropriate fetal and childhood growth.
关键词：smoking cessation;pregnancy;fetal growth;childhood growth