文章基本信息

标题：High-Density Lipoprotein and Prostate Cancer: An Overview
本地全文：下载
作者：Kazuhiko Kotani ; Yoshitaka Sekine ; Shizukiyo Ishikawa 等
期刊名称：Journal of Epidemiology
印刷版ISSN：0917-5040
电子版ISSN：1349-9092
出版年度：2013
卷号：23
期号：5
页码：313-319
DOI：10.2188/jea.JE20130006
出版社：Japan Epidemiological Association
摘要：Prostate cancer is a common disease in modern, developed societies and has a high incidence and mortality. High-density lipoprotein cholesterol (HDL-C) has recently received much attention as a possible risk marker of prostate cancer development and prognosis. In the present article, we summarized findings from epidemiologic studies of the association between HDL-C and prostate cancer. Low HDL-C level was found to be a risk and prognostic factor of prostate cancer in several epidemiologic studies, although the overall linkage between HDL and prostate cancer has not been definitively established. The mechanisms for this association remain uncertain; however, limited data from experimental studies imply a possible role of HDL in the pathophysiology of prostate cancer. More epidemiologic research, in combination with experimental studies, is needed in this field.
关键词：epidemiology;HDL-cholesterol;apoA-I;prostate tumor