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标题：Association Between Dietary Pattern and Serum C-Reactive Protein in Japanese Men and Women
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作者：Hinako Nanri ; Kazuyo Nakamura ; Megumi Hara 等
期刊名称：Journal of Epidemiology
印刷版ISSN：0917-5040
电子版ISSN：1349-9092
出版年度：2011
卷号：21
期号：2
页码：122-131
DOI：10.2188/jea.JE20100110
出版社：Japan Epidemiological Association
摘要：Background: Dietary pattern may influence the risks of cardiovascular disease, atherosclerosis, type 2 diabetes, and metabolic syndrome through its effects on inflammation. We evaluated the association between dietary pattern and serum high-sensitivity C-reactive protein (hs-CRP) in a Japanese population. Methods: In this cross-sectional analysis, we used baseline data from 3905 men and 5640 women (age 40–69 years) who participated in a population-based cohort study between November 2005 and December 2007. Participants with possible inflammation-related diseases, current analgesic use, high hs-CRP levels (≥3000 ng/mL) or extreme dietary energy intake were excluded. We used 46 items from a validated short food frequency questionnaire and examined major dietary patterns by factor analysis. Results: We identified 5 dietary patterns: healthy (high in vegetables and fruit), Western (high in meat and fried foods), seafood (high in shellfish, squid, fish, etc.), bread (high in bread and low in rice), and dessert (high in confections and fruit). After adjustment for age, alcohol use, smoking, physical activity, and body mass index, hs-CRP levels in men were inversely associated with the healthy, bread, and dessert patterns ( P -trend: 0.01, 0.06, and <0.01, respectively) and positively associated with the seafood pattern ( P -trend = 0.02). In women, hs-CRP levels were inversely associated with the healthy pattern ( P -trend = 0.06) and positively associated with the Western pattern ( P -trend = 0.06). Conclusions: The healthy dietary pattern may be associated with suppressed inflammation in Japanese men and women, independently of body mass index and other factors. The sex-specific associations of hs-CRP with other dietary patterns (eg, the seafood pattern) require further study.
关键词：dietary pattern;C-reactive protein;inflammation;factor analysis