文章基本信息

标题：Effects of Airborne Particulate Matter on Respiratory Morbidity in Asthmatic Children
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作者：Lu Ma ; Masayuki Shima ; Yoshiko Yoda 等
期刊名称：Journal of Epidemiology
印刷版ISSN：0917-5040
电子版ISSN：1349-9092
出版年度：2008
卷号：18
期号：3
页码：97-110
DOI：10.2188/jea.JE2007432
出版社：Japan Epidemiological Association
摘要：Background: The effects of airborne particulate matter (PM) are a major human health concern. In this panel study, we evaluated the acute effects of exposure to PM on peak expiratory flow (PEF) and wheezing in children. Methods: Daily PEF and wheezing were examined in 19 asthmatic children who were hospitalized in a suburban city in Japan for approximately 5 months. The concentrations of PM less than 2.5 μm in diameter (PM_2.5) were monitored at a monitoring station proximal to the hospital. Moreover, PM_2.5 concentrations inside and outside the hospital were measured using the dust monitor with a laser diode (PM_2.5(LD)). The changes in PEF and wheezing associated with PM concentration were analyzed. Results: The changes in PEF in the morning and evening were significantly associated with increases in the average concentration of indoor PM_2.5(LD) 24 h prior to measurement (-2.86 L/min [95%CI: -4.12, -1.61] and -3.59 L/min [95%CI: -4.99, -2.20] respectively, for 10-μg/m³ increases). The change in PEF was also significantly associated with outdoor PM_2.5(LD) concentrations, but the changes were smaller than those observed for indoor PM_2.5(LD). Changes in PEF and concentration of stationary-site PM_2.5 were not associated. The prevalence of wheezing in the morning and evening were also significantly associated with indoor PM_2.5(LD) concentrations (odds ratios = 1.014 [95%CI: 1.006, 1.023] and 1.025 [95%CI: 1.013, 1.038] respectively, for 10-μg/m³ increases). Wheezing in the evening was significantly associated with outdoor PM_2.5(LD) concentration. The effects of indoor and outdoor PM_2.5(LD) remained significant even after adjusting for ambient nitrogen dioxide concentrations. Conclusion: Indoor and outdoor PM_2.5(LD) concentrations were associated with PEF and wheezing among asthmatic children. Indoor PM_2.5(LD) had a more marked effect than outdoor PM_2.5(LD) or stationary-site PM_2.5.
关键词：Particulate Matter;Asthma;Peak Expiratory Flow Rate;Respiratory Sounds