文章基本信息

标题：The hOGG1 Ser326Cys Polymorphism Is Not Associated with Colorectal Cancer Risk
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作者：Hye-Won Park ; Il-Jin Kim ; Hio Chung Kang 等
期刊名称：Journal of Epidemiology
印刷版ISSN：0917-5040
电子版ISSN：1349-9092
出版年度：2007
卷号：17
期号：5
页码：156-160
DOI：10.2188/jea.17.156
出版社：Japan Epidemiological Association
摘要：BACKGROUND: Little is known about the genetic risk factors associated with colorectal cancer. Although the Ser326Cys polymorphism of 8-oxoguanine DNA glycosylase ( hOGG1 ) is consistently associated with a range of cancers, there is no consensus regarding this polymorphism and colorectal cancer risk. METHODS: In the present study, conducted in a Korean population, we used the TaqMan assay to investigate whether the hOGG1 Ser326Cys polymorphism was associated with colorectal cancer in 439 colorectal cancer patients and 676 healthy normal controls. We also examined whether the hOGG1 Ser326Cys polymorphism is associated with tumor location, microsatellite instability (MSI) status and tumor-node-metastasis (TNM) stage in colorectal cancer. RESULTS: We found no significant difference between the cancer and control populations in terms of genotype distribution (CC, CG and GG). In addition, we found no association between the hOGG1 Ser326Cys polymorphism and cancer risk, MSI status, TNM stage or tumor location in colorectal cancer patients. CONCLUSIONS: These results suggest that unlike for other cancer types, the hOGG1 Ser326Cys polymorphism is not a major genetic risk factor for colorectal cancer. J Epidemiol 2007; 17: 156-160.
关键词：Clorectal Neoplasms;Polymorphism;Single Nucleotide;hOGG1;DNA Repair