文章基本信息

标题：Genetic polymorphisms in COMT and BDNF influence synchronization dynamics of human neuronal oscillations
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作者：Jaana Simola ; Felix Siebenhühner ; Vladislav Myrov 等
期刊名称：iScience
印刷版ISSN：2589-0042
出版年度：2022
卷号：25
期号：9
页码：1-21
DOI：10.1016/j.isci.2022.104985
语种：English
出版社：Elsevier
摘要：SummaryNeuronal oscillations, their inter-areal synchronization, and scale-free dynamics constitute fundamental mechanisms for cognition by regulating communication in neuronal networks. These oscillatory dynamics have large inter-individual variability that is partly heritable. We hypothesized that this variability could be partially explained by genetic polymorphisms in neuromodulatory genes. We recorded resting-state magnetoencephalography (MEG) from 82 healthy participants and investigated whether oscillation dynamics were influenced by genetic polymorphisms in catechol-O-methyltransferase (COMT) Val158Met and brain-derived neurotrophic factor (BDNF) Val66Met. BothCOMTandBDNFpolymorphisms influenced local oscillation amplitudes and their long-range temporal correlations (LRTCs), while onlyBDNFpolymorphism affected the strength of large-scale synchronization. Our findings demonstrate thatCOMTandBDNFgenetic polymorphisms contribute to inter-individual variability in neuronal oscillation dynamics. Comparison of these results to computational modeling of near-critical synchronization dynamics further suggested thatCOMTandBDNFpolymorphisms influenced local oscillations by modulating the excitation-inhibition balance according to the brain criticality framework.Graphical abstractDisplay OmittedHighlights•Human local oscillation dynamics is influenced by polymorphisms inCOMTandBNDF•COMTandBDNFinfluence oscillation amplitudes and long-range temporal correlations•BDNFpolymorphism affected the strength of large-scale synchronization•Framework of brain criticality linksCOMTandBDNFwith local E/I-balanceBiological sciences; Neuroscience; Cognitive neuroscience