文章基本信息

标题：Heterotypic cell-in-cell structures between cancer and NK cells are associated with enhanced anticancer drug resistance
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作者：Yun-Jeong Choe ; Jin Young Min ; Hyunseong Lee 等
期刊名称：iScience
印刷版ISSN：2589-0042
出版年度：2022
卷号：25
期号：9
页码：1-21
DOI：10.1016/j.isci.2022.105017
语种：English
出版社：Elsevier
摘要：SummaryThe heterotypic CIC structures formed of cancer and immune cells have been observed in tumor tissues. We aimed to assess the feasibility of using heterotypic CICs as a functional biomarker to predict NK susceptibility and drug resistance. The heterotypic CIC-forming cancer cells showed a lower response to NK cytotoxicity and higher proliferative ability than non-CIC cancer cells. After treatment with anticancer drugs, cancer cells that formed heterotypic CICs showed a higher resistance to anticancer drugs than non-CIC cancer cells. We also observed the formation of more CIC structures in cancer cells treated with anticancer drugs than in the non-treated group. Our results confirm the association between heterotypic CIC structures and anticancer drug resistance in CICs formed from NK and cancer cells. These results suggest a mechanism underlying immune evasion in heterotypic CIC cancer cells and provide insights into the anticancer drug resistance of cancer cells.Graphical abstractDisplay OmittedHighlights•Conformation of heterotypic CIC structures formed between cancer and NK cells•Heterotypic CICs exhibit a higher proliferative ability than non-CIC cells•Heterotypic CICs are associated with NK susceptibility•Heterotypic CICs are involved in anticancer drug resistanceCell biology; Biophysics; Cancer