文章基本信息

标题：Pericyte mediates the infiltration, migration, and polarization of macrophages by CD163/MCAM axis in glioblastoma
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作者：Hao Zhang ; Nan Zhang ; Wantao Wu 等
期刊名称：iScience
印刷版ISSN：2589-0042
出版年度：2022
卷号：25
期号：9
页码：1-21
DOI：10.1016/j.isci.2022.104918
语种：English
出版社：Elsevier
摘要：SummaryMicroenvironment cells (MCs) play a critical role in tumor proliferation, progression, and metastasis. However, it has not been adequately addressed whether MCs could be used as a reliable prognostic marker in glioblastoma (GBM). In the current study, the cell pair (CP) score was constructed in 1137 GBM samples based on the cell pair algorithm and Gaussian finite mixture model (GMM) and was verified in 73 GBM samples from the Xiangya cohort. CP score predicted GBM patients’ survival and response to anti-PD-1 treatment with high sensitivity. Macrophage markers CD68 and CD163 were co-expressed with pericyte markers MCAM and MG2. Pericyte could mediate the infiltration, migration, and M2 type polarization of macrophages by MCAM. The CP score was a valuable tool for predicting survival outcomes and guiding immunotherapy for GBM patients. Cell pair pericyte/macrophage and gene pair CD163/MCAM were biologically significant in the tumor microenvironment of GBM.Graphical abstractDisplay OmittedHighlights•We introduced a cell pair algorithm for developing a robust immune signature in GBM•The immune signature helps identify GBM patients with better immunotherapy responses•Macrophage/pericyte and CD163/MCAM significantly affected GBM patients’ survival•Pericytes mediate macrophage infiltration, migration, and M2 type polarization in GBMImmunology; Biocomputational method; Genomic analysis; Cancer