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标题：Evolving social behavior through selection of single-cell adhesion in Dictyostelium discoideum
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作者：Sandrine Adiba ; Mathieu Forget ; Silvia De Monte 等
期刊名称：iScience
印刷版ISSN：2589-0042
出版年度：2022
卷号：25
期号：9
页码：1-21
DOI：10.1016/j.isci.2022.105006
语种：English
出版社：Elsevier
摘要：SummaryThe social amoebaDictyostelium discoideumcommonly forms chimeric fruiting bodies. Genetic variants that produce a higher proportion of spores are predicted to undercut multicellular organization unless cooperators assort positively. Cell adhesion is considered a primary factor driving such assortment, but evolution of adhesion has not been experimentally connected to changes in social performance. We modified by experimental evolution the efficiency of individual cells in attaching to a surface. Surprisingly, evolution appears to have produced social cooperators irrespective of whether stronger or weaker adhesion was selected. Quantification of reproductive success, cell-cell adhesion, and developmental patterns, however, revealed two distinct social behaviors, as captured when the classical metric for social success is generalized by considering clonal spore production. Our work shows that cell mechanical interactions can constrain the evolution of development and sociality in chimeras and that elucidation of proximate mechanisms is necessary to understand the ultimate emergence of multicellular organization.Graphical abstractDisplay OmittedHighlights•Cooperative behavior evolved as a pleiotropic effect of selection for surface adhesion•Multicellular development of evolved lines with the ancestor follows two different paths•A metric of social behavior including clonal development differentiates these two pathsEvolution of social behavior; Multicellularity; Evolutionary biology; Adhesion; Experimental evolution