文章基本信息

标题：Intramodal cortical plastic changes after moderate visual impairment in human amblyopia
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作者：Matin Mortazavi ; Kiera Aigner ; Jessica E. Antono 等
期刊名称：iScience
印刷版ISSN：2589-0042
出版年度：2022
卷号：25
期号：9
页码：1-16
DOI：10.1016/j.isci.2022.104871
语种：English
出版社：Elsevier
摘要：SummaryEarly blindness results in alterations in the neural responses to auditory stimuli. Here we show that even moderately reduced vision in one eye early in life is sufficient to induce neural plastic changes in voice processing. We asked individuals with reduced visual acuity in one eye due to amblyopia to attend to vocal cues during electroencephalogram recording. We found enhanced frontal auditory responses at 125 ms–225 ms, which were correlated with reduced vision in the amblyopic eye, but not the fellow eye. Our results indicate intramodal reorganization, typically observed after congenital profound visual deprivation.Graphical abstractDisplay OmittedHighlights•Profound vision loss leads to enhanced neural signals in response to auditory stimuli•Individuals with amblyopia show enhanced auditory event-related potential (ERP) responses compared to controls•Enhanced auditory ERP responses correlated with reduced vision in the amblyopic eye•Neural plastic changes occur even after moderate vision loss in humans with amblyopiaBiological sciences; Sensory neuroscience