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  • 标题:The role of lipid peroxidation in neurological disorders
  • 本地全文:下载
  • 作者:Mototada Shichiri
  • 期刊名称:Journal of Clinical Biochemistry and Nutrition
  • 印刷版ISSN:0912-0009
  • 电子版ISSN:1880-5086
  • 出版年度:2014
  • 卷号:54
  • 期号:3
  • 页码:151-160
  • DOI:10.3164/jcbn.14-10
  • 出版社:The Society for Free Radical Research Japan
  • 摘要:There has been much evidence demonstrating the involvement of oxidative stress in the pathology of neurological disorders. Moreover, the vulnerability of the central nervous system to reactive oxygen species mediated injury is well established since neurons consume large amounts of oxygen, the brain has many areas containing high iron content, and neuronal mitochondria generate large amounts of hydrogen peroxide. Furthermore, neuronal membranes are rich in polyunsaturated fatty acids, which are particularly susceptible to oxidative stress. Recently, the biological roles of products produced by lipid peroxidation have received much attention, not only for their pathological mechanisms associated with neurological disorders, but also for their practical clinical applications as biomarkers. Here, we discuss the production mechanisms of reactive oxygen species in some neurological disorders, including Alzheimer’s disease, Down syndrome, Parkinson’s disease, and stroke. We also describe lipid peroxidation biomarkers for evaluating oxidative stress.
  • 关键词:lipid peroxidation;neurological disorder;Alzheimer’s disease;Down syndrome;Parkinson’s disease;stroke
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