文章基本信息

标题：Singlet molecular oxygen-quenching activity of carotenoids: relevance to protection of the skin from photoaging
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作者：Junji Terao ; Yuko Minami ; Noriko Bando 等
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：2011
卷号：48
期号：1
页码：57-62
DOI：10.3164/jcbn.11-008FR
出版社：The Society for Free Radical Research Japan
摘要：Carotenoids are known to be potent quenchers of singlet molecular oxygen [O₂ (¹Δ_g)]. Solar light-induced photooxidative stress causes skin photoaging by accelerating the generation of reactive oxygen species via photodynamic actions in which O₂ (¹Δ_g) can be generated by energy transfer from excited sensitizers. Thus, dietary carotenoids seem to participate in the prevention of photooxidative stress by accumulating as antioxidants in the skin. An in vivo study using hairless mice clarified that a O₂ (¹Δ_g) oxygenation-specific peroxidation product of cholesterol, cholesterol 5α-hydroperoxide, accumulates in skin lipids due to ultraviolet-A exposure. Matrix metalloproteinase-9, a metalloproteinase family enzyme responsible for the formation of wrinkles and sagging, was enhanced in the skin of ultraviolet-A -irradiated hairless mice. The activation of metalloproteinase-9 and the accumulation of 5α-hydroperoxide, as well as formation of wrinkles and sagging, were lowered in mice fed a β-carotene diet. These results strongly suggest that dietary β-carotene prevents the expression of metalloproteinase-9 (at least in part), by inhibiting the photodynamic action involving the formation of 5α-hydroperoxide in the skin. Intake of β-Carotene therefore appears to be helpful in slowing down ultraviolet-A -induced photoaging in human skin by acting as a O₂ (¹Δ_g) quencher.
关键词：singlet molecular oxygen;carotenoids;photoaging;cholesterol hydroperoxide;matrix metalloproteinase